Leucoselect Grape seed Proanthocyanidin extract: What It Is, Benefits, Dosage, and Sources

Nutrienting Team

January 13, 202617 min read

Leucoselect grape seed proanthocyanidin extract is a specific, standardized form of grape seed extract. It is primarily known for its high concentration of proanthocyanidins, a type of flavonoid. These compounds are naturally occurring antioxidants found in various plants, with grape seeds being a particularly rich source. What distinguishes Leucoselect is its proprietary extraction and formulation process, often involving Indena's Phytosome® technology, which aims to enhance the bioavailability of these beneficial compounds. This article explores what Leucoselect grape seed proanthocyanidin extract is, its potential benefits, typical dosages, and where it originates.

Leucoselect® Indena Phytosome

Leucoselect® is a registered trademark of Indena S.p.A., an Italian company specializing in botanical derivatives for pharmaceutical and health product industries. The "Leucoselect" designation indicates a grape seed extract that is standardized to contain a high percentage of proanthocyanidins, typically around 95%. This standardization is important because the concentration of active compounds can vary significantly between different grape seed extracts.

The "Phytosome" aspect refers to Indena's patented technology designed to improve the absorption of plant extracts. Many plant compounds, including proanthocyanidins, can be poorly absorbed by the human body due to their size and chemical structure. Phytosome technology involves complexing the plant extract with phospholipids, such as phosphatidylcholine. This complex is believed to mimic the body's natural absorption processes, allowing the active compounds to pass more readily through cell membranes and into the bloodstream.

In practical terms, this means that a Leucoselect Phytosome product aims to deliver more of the beneficial proanthocyanidins to the body compared to a non-Phytosome grape seed extract, even if both contain the same initial quantity of the extract. This enhanced bioavailability is a key differentiator when considering Leucoselect for its potential health benefits. For instance, if a standard grape seed extract might require a higher dose to achieve a certain systemic effect, a Leucoselect Phytosome formulation might achieve a similar effect at a lower dose due to improved absorption. This can be a trade-off between cost and efficacy, as the specialized formulation often comes with a higher price point.

LEUCOSELECT PHYTOSOME MODULATES SERUM ... - PMC

Research published on platforms like PubMed Central (PMC) often investigates the efficacy of specific formulations like Leucoselect Phytosome. When a study mentions "LEUCOSELECT PHYTOSOME MODULATES SERUM...", it typically refers to investigations into how this specific grape seed extract influences various markers or compounds in the bloodstream. The term "modulates" suggests that the extract is being studied for its ability to regulate, increase, or decrease certain physiological parameters.

For example, studies might explore Leucoselect Phytosome's impact on serum lipid levels (like cholesterol or triglycerides), inflammatory markers (like C-reactive protein), or antioxidant capacity. The focus of such research is often to provide a scientific basis for the purported health benefits of the extract. These studies are crucial for understanding the practical implications and potential benefits of Leucoselect. They provide data points on how the extract interacts with biological systems, which helps in clarifying its uses and edge cases. Without such research, claims about efficacy would largely remain anecdotal.

It's important to note that while PMC hosts peer-reviewed literature, the findings from individual studies should be considered within the broader context of scientific research. A single study, even if well-conducted, does not always provide definitive proof of a widespread effect, and replication of results is often needed. However, these specific studies on Leucoselect Phytosome are valuable for understanding the targeted applications and mechanisms of action attributed to this particular extract.

Grape Seed Extract (formerly O.P.C.-100)

Grape Seed Extract (GSE) is a broad term for supplements derived from the seeds of grapes. These extracts are rich in various polyphenols, with proanthocyanidins being the most prominent. Before the advent of highly standardized and branded extracts like Leucoselect, many grape seed supplements were simply labeled as "O.P.C.-100" or similar, referring to Oligomeric Proanthocyanidin Complexes (OPCs).

The "O.P.C.-100" designation typically indicated a product containing 100 milligrams of proanthocyanidins per serving, or sometimes that it was a 100% extract. However, these early formulations often lacked the precise standardization and enhanced bioavailability features found in newer, proprietary extracts. The shift from generic "O.P.C.-100" to specific brands like Leucoselect reflects an evolution in the supplement industry towards more scientifically backed and consistent products.

The primary difference lies in the level of standardization and the potential for improved absorption. While both older "O.P.C.-100" products and Leucoselect aim to deliver the benefits of grape seed proanthocyanidins, Leucoselect, particularly in its Phytosome form, often claims superior efficacy due to its optimized delivery system. For consumers, this means that comparing a generic "O.P.C.-100" product with Leucoselect might not be an apples-to-apples comparison, even if the stated proanthocyanidin content appears similar on the label. The "how" the body utilizes these compounds can be as important as the "how much" is present.

Characterization of Proanthocyanidins from Grape Seeds

Characterization of proanthocyanidins from grape seeds involves identifying and quantifying the specific types and amounts of these compounds present in the extract. Proanthocyanidins are not a single compound but rather a class of polymeric flavonoids. They range from monomers (like catechin and epicatechin) to dimers, trimers, and higher-order oligomers and polymers. The specific composition – which types of proanthocyanidins are present and in what ratios – can influence the biological activity of the extract.

Grape seeds are particularly rich in proanthocyanidins, especially oligomeric proanthocyanidins (OPCs), which are smaller polymers that are generally considered more bioavailable than larger, more complex polymers. The characterization process often uses advanced analytical techniques such as High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to separate and identify these individual compounds.

This detailed characterization is crucial for several reasons:

Quality Control: It ensures that a product like Leucoselect consistently contains the specified amount and type of proanthocyanidins, which is vital for reproducible research and consistent consumer experience.
Bioactivity: Different proanthocyanidin structures may have varying biological activities. Understanding the specific composition helps in linking the extract to particular health benefits. For instance, some proanthocyanidins might be more effective at scavenging free radicals, while others might have stronger effects on vascular health.
Standardization: It allows manufacturers to standardize their extracts, ensuring that each batch meets certain specifications. This moves beyond simply stating "grape seed extract" to guaranteeing a certain level of active compounds.

For the consumer, this means that a product like Leucoselect, which undergoes rigorous characterization, offers a higher degree of certainty regarding its active ingredient profile compared to a less characterized generic grape seed extract. This scientific rigor is part of what differentiates premium extracts in the market.

Nutri Supreme Grapeseed Extract Leucoselect ...

When a product is labeled "Nutri Supreme Grapeseed Extract Leucoselect...", it indicates that the manufacturer, in this case, "Nutri Supreme," is utilizing the branded Leucoselect ingredient from Indena in their supplement. This is a common practice in the supplement industry where ingredient suppliers develop specialized, well-researched ingredients, and then supplement brands incorporate these ingredients into their final products.

The inclusion of "Leucoselect" in the product name or description signifies that the brand is leveraging the reputation and scientific backing associated with Indena's specific grape seed extract. This can be a selling point for consumers who are looking for a product with a known and potentially enhanced profile of proanthocyanidins.

For the consumer, seeing "Leucoselect" on a product label, regardless of the specific brand (e.g., Nutri Supreme, Central Market), generally means:

Standardized Quality: The grape seed extract used is standardized to a high percentage of proanthocyanidins, typically around 95%.
Potential Bioavailability Enhancement: If the product specifies "Leucoselect Phytosome," it suggests the inclusion of Indena's patented technology for improved absorption.
Research Backing: The ingredient itself has been subject to scientific investigation, and the brand is aligning with that research.

However, it's still important to examine the full product label for other ingredients, dosage per serving, and any additional claims made by the specific brand, as the final formulation and marketing can vary even when using the same core ingredient. For example, one brand might combine Leucoselect with other antioxidants, while another might offer it as a standalone product.

Central Market Grape Seed Extract Leucoselect 50 mg ...

Similar to the "Nutri Supreme" example, when a product from a retailer like "Central Market" is labeled "Grape Seed Extract Leucoselect 50 mg...", it signifies that Central Market is sourcing and including Indena's Leucoselect ingredient in their own branded supplement line. The "50 mg" indicates the amount of the Leucoselect extract per serving.

This example highlights the common practice of supplement brands utilizing specific, high-quality raw ingredients from specialized suppliers. The "50 mg" dosage is a critical piece of information for consumers. Depending on the intended use and the concentration of proanthocyanidins within that 50 mg, this dosage can be evaluated against recommended or studied dosages.

It's crucial for consumers to understand that "50 mg of Leucoselect" does not necessarily equate to "50 mg of pure proanthocyanidins." Leucoselect itself is an extract, and its proanthocyanidin content is standardized. For example, if Leucoselect is standardized to 95% proanthocyanidins, then 50 mg of Leucoselect would provide 47.5 mg of proanthocyanidins. This distinction is important for accurate dosage comparison.

When evaluating such a product, consider:

The total amount of Leucoselect per serving.
The percentage of proanthocyanidins guaranteed within that Leucoselect extract.
Whether it specifies "Phytosome" technology, which would imply enhanced absorption.
Comparison to research-backed dosages for specific health benefits.

For instance, if scientific studies suggest a beneficial effect at 150-300 mg of proanthocyanidins daily, a product offering 50 mg of Leucoselect (yielding ~47.5 mg proanthocyanidins) might require multiple servings to reach that level. This scenario illustrates the practical implications for consumers in determining if a product aligns with their needs and expectations based on available information.

Leucoselect Grape Seed Proanthocyanidin Extract: Benefits, Dosage, and Natural Sources

Leucoselect grape seed proanthocyanidin extract is primarily valued for its high concentration of proanthocyanidins, which are potent antioxidants. These compounds are believed to contribute to a range of potential health benefits, primarily by combating oxidative stress and supporting various physiological functions.

Potential Benefits of Leucoseelect Grape Seed Proanthocyanidin Extract

The reported benefits of grape seed proanthocyanidins, and by extension Leucoselect due to its standardized nature and potential for enhanced bioavailability, stem largely from their antioxidant and anti-inflammatory properties.

Antioxidant Support: Proanthocyanidins are powerful free radical scavengers. They help neutralize harmful free radicals in the body, which can cause oxidative damage to cells and contribute to aging and various chronic diseases.
Cardiovascular Health: This is one of the most frequently cited areas of benefit. Leucoselect may support cardiovascular health by:

* Improving blood vessel elasticity: Helping maintain healthy blood pressure levels already within the normal range.

* Reducing oxidative damage to LDL cholesterol: Which is a factor in arterial plaque formation.

* Supporting healthy circulation: Especially in the microvasculature.

Skin Health: The antioxidant properties can protect skin cells from environmental damage (like UV radiation) and support collagen and elastin integrity, potentially contributing to skin elasticity and a reduction in the appearance of fine lines. Some studies suggest it may aid in wound healing.
Cognitive Function: By protecting brain cells from oxidative stress and supporting healthy blood flow to the brain, proanthocyanidins may play a role in maintaining cognitive function.
Anti-inflammatory Effects: While not a primary anti-inflammatory agent like NSAIDs, proanthocyanidins can modulate inflammatory pathways, potentially contributing to overall cellular health.
Eye Health: The antioxidants may help protect the eyes from oxidative damage, particularly the delicate structures of the retina.

It's important to remember that while these potential benefits are supported by research on grape seed extract and its components, individual results can vary. The efficacy of a supplement depends on many factors, including the individual's diet, lifestyle, and overall health status.

Recommended Dosage and Administration

Determining a precise, universally recommended dosage for Leucoselect grape seed proanthocyanidin extract can be challenging, as it depends on the specific health goal, the individual's body weight, and the concentration of the extract. However, based on general research on grape seed extract and common supplement formulations, some guidelines can be observed.

General Antioxidant Support: For general antioxidant support, dosages often range from 50 mg to 100 mg of Leucoselect extract per day, which, depending on standardization (e.g., 95% proanthocyanidins), would deliver approximately 47.5 mg to 95 mg of proanthocyanidins.
Cardiovascular Health: For more targeted cardiovascular support, studies have sometimes used higher doses, in the range of 150 mg to 300 mg of proanthocyanidins daily. This might translate to a higher dose of Leucoselect extract, or multiple servings of a lower-dose product.
Specific Conditions: For specific health concerns, higher dosages have been explored in research, sometimes up to 600 mg per day of standardized grape seed extract. However, such dosages should only be considered under the guidance of a healthcare professional.

Important Considerations for Dosage:

Bioavailability: If using Leucoselect Phytosome, the enhanced absorption might mean that a lower dose could provide similar benefits to a higher dose of a non-Phytosome extract. Always refer to the product label for specific instructions.
Timing: Leucoselect can typically be taken with or without food. Some prefer to take it with meals to minimize any potential mild digestive upset, though this is rare.
Consistency: Like many supplements, consistent daily intake is generally recommended for potential long-term benefits.
Consult a Healthcare Professional: Before starting any new supplement, especially if you have existing health conditions, are pregnant or breastfeeding, or are taking other medications, it is advisable to consult a doctor or a qualified healthcare provider. They can offer personalized advice and help determine an appropriate dosage for your specific needs.

Natural Sources of Proanthocyanidins

While Leucoselect is a concentrated extract, proanthocyanidins are naturally present in various plant foods. Incorporating these foods into your diet can provide a broader spectrum of beneficial plant compounds.

The primary natural source for the extract itself is, of course, grape seeds. However, other foods rich in proanthocyanidins include:

Grapes (especially skins and seeds): Red, purple, and black grapes are particularly rich.
Berries: Cranberries, blueberries, chokeberries, and black currants are excellent sources. Cranberries are especially noted for their A-type proanthocyanidins, which have specific benefits for urinary tract health.
Apples: Especially the skin.
Cocoa/Dark Chocolate: High-quality dark chocolate (with a high cocoa content) is a significant source.
Tea: Green tea and black tea contain proanthocyanidins, alongside other flavonoids.
Some Nuts: Pecans and hazelnuts contain these compounds.

While dietary sources provide proanthocyanidins along with other nutrients and fiber, the concentration in a standardized extract like Leucoseelect is significantly higher. This is why supplements are used when a targeted, higher intake of these specific compounds is desired for therapeutic or health-supportive purposes.

Comparison: Leucoselect vs. Generic Grape Seed Extract

Understanding the distinctions between a branded, standardized extract like Leucoselect and a generic grape seed extract is key for informed decision-making.

Feature	Leucoselect Grape Seed Proanthocyanidin Extract (e.g., Phytosome)	Generic Grape Seed Extract (GSE)
Standardization	Highly standardized (e.g., 95% proanthocyanidins)	Variable; may or may not be standardized, or to a lower degree
Bioavailability	Often enhanced (e.g., Phytosome technology for better absorption)	Typically standard absorption; lower bioavailability possible
Research & Backing	Specific research often conducted on the branded ingredient	General research on GSE, not necessarily on the specific product
Consistency	High batch-to-batch consistency in active compounds	Can vary significantly between batches and manufacturers
Cost	Generally higher due to proprietary technology and research	Generally lower
Manufacturer/Supplier	Sourced from specific, reputable ingredient suppliers (e.g., Indena)	Can come from various, sometimes unknown, sources
Labeling Clarity	Usually clearly states "Leucoselect" and percentage standardization	May simply state "Grape Seed Extract" or "O.P.C."
Target Audience	Consumers seeking premium, scientifically-backed ingredients	Consumers looking for a more basic or cost-effective option

This comparison highlights that while both types of products derive from grape seeds, Leucoselect aims to offer a more refined, consistent, and potentially more effective product through its specialized processing and standardization.

FAQ

Who should not take grapeseed extract?

While generally considered safe for most healthy adults, certain individuals should exercise caution or avoid grape seed extract:

Individuals on Blood Thinners: Grape seed extract, particularly at higher doses, may have mild anti-platelet effects, potentially increasing the risk of bleeding when taken with anticoagulant medications (like warfarin, aspirin, clopidogrel).
Those with Bleeding Disorders: Due to its potential anti-platelet effects, individuals with diagnosed bleeding disorders should avoid it.
Before Surgery: It's often recommended to stop taking grape seed extract at least two weeks before any scheduled surgery to minimize the risk of bleeding.
Pregnant or Breastfeeding Women: There is insufficient research on the safety of grape seed extract in these populations, so it's generally advised to avoid use.
Children: Limited research exists on grape seed extract's safety and efficacy in children; therefore, it's usually not recommended.
Individuals with Grape Allergies: While rare, a person allergic to grapes should avoid grape seed extract.
Those with Certain Medical Conditions: If you have a serious medical condition or are on multiple medications, always consult your doctor before starting any new supplement.

What is the benefit of Leucoselect?

The primary benefit of Leucoselect grape seed proanthocyanidin extract lies in its high concentration of bioavailable proanthocyanidins, which are potent antioxidants. This translates to potential benefits such as:

Strong Antioxidant Protection: Combating oxidative stress and free radical damage throughout the body.
Support for Cardiovascular Health: Helping maintain healthy blood pressure, improving blood vessel elasticity, and supporting circulation.
Skin Health Support: Protecting skin cells from environmental damage and supporting collagen integrity.
Anti-inflammatory Effects: Modulating inflammatory pathways.
Potential for Enhanced Absorption: Particularly with Leucoselect Phytosome, meaning the body may utilize more of the active compounds compared to generic extracts.

What is the grape seed trick to remove wrinkles?

There isn't a scientifically recognized "grape seed trick" that can directly or instantly remove wrinkles. The idea likely stems from the antioxidant and collagen-supporting properties attributed to grape seed extract. Proanthocyanidins found in grape seeds can help protect skin cells from oxidative damage, which is a factor in skin aging and wrinkle formation. They may also support the integrity of collagen and elastin, proteins crucial for skin elasticity and firmness.

Therefore, while grape seed extract, when taken internally as a supplement or applied topically in skincare products, might contribute to overall skin health and potentially help in preventing or reducing the appearance of wrinkles over time by supporting skin structure and protecting against damage, it is not a quick fix or a "trick" for wrinkle removal. Expecting immediate or dramatic results solely from grape seed extract for existing wrinkles is unrealistic. Consistent, long-term use in conjunction with a healthy lifestyle and comprehensive skincare routine would be more aligned with its potential benefits.

Conclusion

A more grounded way to view thisseed proanthocyanidin extract represents a specialized and standardized form of grape seed extract, distinguished by its high concentration of beneficial proanthocyanidins and often enhanced bioavailability through technologies like Phytosome. It is primarily sought after for its potent antioxidant properties and potential role in supporting cardiovascular health, skin integrity, and general cellular protection. While generic grape seed extracts offer similar compounds, Leucoselect aims for greater consistency and efficacy due to its rigorous processing and formulation.

For curious readers seeking trustworthy information, understanding that Leucoselect is a premium ingredient within the broader category of grape seed extracts is key. When considering a supplement, paying attention to the specific form (e.g., Phytosome), the stated dosage of the extract, and the guaranteed proanthocyanidin content allows for a more informed choice. As with any supplement, consulting a healthcare professional is advisable, especially for specific health concerns or if already on medication, to ensure it aligns with individual health needs and circumstances.